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脑肠相通:情绪益生菌PS128对精神障碍疾病的调节机制

新闻报道:脑肠相通:情绪益生菌PS128对精神障碍疾病的调节机制

精神障碍疾病作为我国患病率高、复发率高的常见疾病之一,严重影响了患者的生活质量和社会功能。因此,如何有效预防、早期干预并提升治疗效果,已成为医疗界和公共卫生领域亟待解决的重大课题。近日,中华医学会第二十二次全国精神医学大会(CSP2024)在沈阳隆重召开。作为我国精神医学领域规格最高、规模最大、学科覆盖最广的学术盛会,该会议吸引了众多国内外精神医学领域的顶尖专家,共同探讨精神卫生领域的前沿研究和未来发展趋势。其中,肠道菌群与精神类疾病的关联作为近年来的研究热点之一,成为与会学者热议的焦点。

(中华医学会第二十二次精神医学学术会议)

研究发现,肠道菌群与精神类疾病之间的关联,主要通过“脑-肠轴”机制得以体现。所谓“脑-肠轴”,是指肠道与大脑之间的双向通讯系统,包括神经、免疫、内分泌等多个层面,各组分之间相互影响,相互作用。例如,肠道菌群失调会引发神经系统的异常反应,导致包括抑郁、焦虑、孤独症谱系障碍之类的精神类疾病的发生或加重。

在了解肠道微生物群作为神经精神系统疾病治疗靶点的潜力后,关键问题在于如何将这一理论应用于临床。在本次会议中,北京安定医院儿童精神科主任提到,特殊益生菌和催产素并用在孤独症等精神障碍疾病的干预中具有积极作用。她补充道,纳入35名3-20岁的孤独症受试者,两组分别进行随机双盲安慰剂对照试验,自16周起同时给予鼻喷催产素。结果显示,一组在接受28周的情绪益生菌PS128和催产素并用干预后,ABC和SRS评分有所改善,CGI亦有所改善。这些结果进一步支持了情绪益生菌PS128在孤独症治疗中的应用潜力。

本次展会中,情绪益生菌PS128也应邀参展,并吸引了众多专家和参会者的关注。

(精神益生菌PS128展位)

(精神益生菌PS128展位)

情绪益生菌PS128是何方神圣?又是如何发挥作用的呢?据悉,情绪益生菌PS128是“亚洲益生菌权威”蔡英杰教授及其团队开发的益生菌,已在多项临床试验中显示出对多动症、焦虑和情绪不稳等症状的改善作用。其机制主要体现在以下几个方面:

平衡神经递质血清素和多巴胺:血清素和多巴胺是神经系统中关键的两种神经递质。血清素与情绪和社会行为密切相关,而多巴胺则与动机、愉悦感和学习能力直接联系。情绪益生菌PS128通过调节这两种神经递质的水平,改善儿童的情绪和神经系统功能,从而提高学习兴趣和记忆力。

增加脑源性神经营养因子(BDNF)和神经生长因子(NGF):BDNF和NGF是神经系统中重要的神经营养因子,分别负责增强神经元的可塑性和促进神经修复。通过提升这些营养因子的水平,情绪益生菌PS128助力改善青少年的认知功能和神经系统健康。

(脑源性神经营养因子BDNF表达异常可能会引发抑郁症等精神障碍疾病)

降低压力激素皮质醇(Cortisol):皮质醇是应激反应中的关键激素,长期高水平的皮质醇会导致免疫力下降、睡眠障碍和情绪波动等问题。情绪益生菌PS128已被证实能够有效降低压力激素的水平,缓解患者高压状态下的身心不适。

未来,随着更多临床研究的开展和技术的进步,情绪益生菌在精神类疾病干预中的应用前景愈加广阔。而情绪益生菌PS128作为其中的领先者,已成为精神疾病干预的有效补充手段,为患者带来更精准、个性化的干预方案,助力他们走向身心平衡与健康。

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